A bomb squad has reportedly been dispatched to Manhattan's Port Authority Bus Terminal following the "large" blast this morning.
Taking to Twitter, one shocked woman wrote: "Just was stuck in a running stampede at port authority bus terminal due to bomb scare."
She added: "Cops EVERYWHERE."
The New York Police Department (NYPD) confirmed it was responding to reports of an explosion at 42nd Street and 8th Avenue.
A bomb squad has reportedly been dispatched to the Manhattan bus station (Image: GN4GN.COM: WATCHMEN OF YHVH)
The force tweeted: "The NYPD is responding to reports of an explosion of unknown origin at 42nd Street and 8th Ave, Manhattan.
"The A, C and E line are being evacuated at this time.
"Info is preliminary, more when available."
There are reports that one person has been arrested following the alleged explosion, although these remain unconfirmed.
It is thought all traffic is being rerouted away from the area.
Some subway train lines at the station have been...
Some subway train lines at the station have been...